BAX-induced cell death may not require interleukin 1 -converting enzyme-like proteases
نویسندگان
چکیده
منابع مشابه
Interleukin I J Converting Enzyme-like Proteases Are Essential for p53-mediated Transcriptionally Dependent Apoptosis1
p53-mediated apoptosis in baby rat kidney (BRK) cell lines transformed by EIA and p53(vaIl35) requires a transcriptionally functional p53. Coexpression of the El B 19K protein in BRK cell lines transformed by EIA and p53(vaIl35) rescues cells from p53-mediated apoptosis, and this is paralleled by the absence of both lamin and poly(ADP-nbose) polymerase cleavage. Therefore, the role of interleuk...
متن کاملBax-induced apoptotic cell death.
A is an ordered cascade of enzymatic events that culminates in cell death and the cleavage of DNA into characteristic nucleosomal fragments. It is operative during embryonic development and, during adult life, plays a key role in various physiological processes, such as tissue remodeling and execution and regulation of the immune response. The consequences of inappropriate apoptotic responses a...
متن کاملArsenic trioxide-induced death of neuroblastoma cells involves activation of Bax and does not require p53.
PURPOSE On the basis of clinical studies showing that arsenic trioxide (As(2)O(3)), via an apoptotic mechanism, and with minimal toxicity induces complete remission in patients with refractory acute promyelocytic leukemia and that multidrug-resistant and p53-mutated neuroblastoma cells are sensitive to As(2)O(3) both in vitro and in vivo, we searched for molecular mechanisms involved in the As(...
متن کاملIonizing radiation-induced, Bax-mediated cell death is dependent on activation of cysteine and serine proteases.
Bcl-2 family proteins and interleukin-1-beta converting enzyme/Caenorhabditis elegans cell death gene-3 (ICE/CED-3) family proteases (caspases) represent the basic regulators of apoptosis. However, the precise mechanism by which they interact is unclear. In this study, we found that gamma-radiation-induced apoptosis of leukemia cells was associated with activation of multiple caspases and bax u...
متن کاملSelf-regulation of BAX-induced cell death
Apoptosis, a form of programmed cell death, is a process in multicellular organisms responsible for normal tissue development and homeostasis. The intrinsic pathway of apoptosis is principally regulated by protein-protein interactions within the BCL-2 family of proteins, which can prevent or promote mitochondrial dysfunction. There are over twenty BCL-2 family proteins grouped together based on...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1996
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.93.25.14559